6NNH

Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil

6NNH の概要

• エントリーDOI: 10.2210/pdb6nnh/pdb
• 分子名称: Dihydrofolate reductase, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: antifolate, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38006.53

構造登録者

Giudice, J.H.P.,Ribeiro, J.A.,Dias, M.V.B. (登録日: 2019-01-15, 公開日: 2019-07-17, 最終更新日: 2023-10-11)

• 主引用文献: Ribeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B.; Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.; Acta Crystallogr D Struct Biol, 75:682-693, 2019; PubMed: 31282477; DOI: 10.1107/S205979831900901X

実験手法

X-RAY DIFFRACTION (1.523 Å)