6NNG
Tubulin-RB3_SLD-TTL in complex with compound DJ95
Summary for 6NNG
Entry DOI | 10.2210/pdb6nng/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine, cancer, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 264791.21 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-01-15, release date: 2019-07-10, Last modification date: 2019-12-04) |
Primary citation | Arnst, K.E.,Wang, Y.,Lei, Z.N.,Hwang, D.J.,Kumar, G.,Ma, D.,Parke, D.N.,Chen, Q.,Yang, J.,White, S.W.,Seagroves, T.N.,Chen, Z.S.,Miller, D.D.,Li, W. Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy. Mol.Pharmacol., 96:73-89, 2019 Cited by PubMed: 31043459DOI: 10.1124/mol.118.114801 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.397 Å) |
Structure validation
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