6NNG

Tubulin-RB3_SLD-TTL in complex with compound DJ95

6NNG の概要

• エントリーDOI: 10.2210/pdb6nng/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine, cancer, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 264791.21

構造登録者

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (登録日: 2019-01-15, 公開日: 2019-07-10, 最終更新日: 2019-12-04)

• 主引用文献: Arnst, K.E.,Wang, Y.,Lei, Z.N.,Hwang, D.J.,Kumar, G.,Ma, D.,Parke, D.N.,Chen, Q.,Yang, J.,White, S.W.,Seagroves, T.N.,Chen, Z.S.,Miller, D.D.,Li, W.; Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.; Mol.Pharmacol., 96:73-89, 2019; PubMed: 31043459; DOI: 10.1124/mol.118.114801

実験手法

X-RAY DIFFRACTION (2.397 Å)