6NMV

Non-Blocking Fab 218 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1

6NMV の概要

• エントリーDOI: 10.2210/pdb6nmv/pdb
• 関連するPDBエントリー: 6NMR 6NMS 6NMT 6NMU
• 分子名称: Tyrosine-protein phosphatase non-receptor type substrate 1, Fab 218 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 218 anti-SIRP-alpha antibody Variable Light Chain, ... (4 entities in total)
• 機能のキーワード: sirp-alpha, signal regulatory protein alpha, signal-regulatory protein alpha, tyrosine-protein phosphatase non-receptor type substrate 1, cd47, cluster of differentiation 47, anti-sirp-alpha antibody, blocking anti-sirp-alpha antibody, non-blocking anti-sirp-alpha antibody, kick-off anti-sirp-alpha antibody, anti-sirp-alpha antibody in complex with sirp-alpha, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 59513.22

構造登録者

Wibowo, A.S.,Carter, J.J.,Sim, J. (登録日: 2019-01-11, 公開日: 2019-08-07, 最終更新日: 2019-08-14)

• 主引用文献: Sim, J.,Sockolosky, J.T.,Sangalang, E.,Izquierdo, S.,Pedersen, D.,Harriman, W.,Wibowo, A.S.,Carter, J.,Madan, A.,Doyle, L.,Harrabi, O.,Kauder, S.E.,Chen, A.,Kuo, T.C.,Wan, H.,Pons, J.; Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha.; Mabs, 11:1036-1052, 2019; PubMed: 31257988; DOI: 10.1080/19420862.2019.1624123

実験手法

X-RAY DIFFRACTION (2.61 Å)