6NM8
IgV-V76T BMS compound 105
Summary for 6NM8
Entry DOI | 10.2210/pdb6nm8/pdb |
Descriptor | Programmed cell death 1 ligand 1, N-({2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)-D-alanine (2 entities in total) |
Functional Keywords | fragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 30059.37 |
Authors | |
Primary citation | Perry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S. Fragment-based screening of programmed death ligand 1 (PD-L1). Bioorg. Med. Chem. Lett., 29:786-790, 2019 Cited by PubMed: 30728114DOI: 10.1016/j.bmcl.2019.01.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.792 Å) |
Structure validation
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