6NM8

IgV-V76T BMS compound 105

6NM8 の概要

• エントリーDOI: 10.2210/pdb6nm8/pdb
• 分子名称: Programmed cell death 1 ligand 1, N-({2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)-D-alanine (2 entities in total)
• 機能のキーワード: fragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30059.37

構造登録者

Perry, E.,Zhao, B.,Fesik, S. (登録日: 2019-01-10, 公開日: 2019-02-20, 最終更新日: 2023-10-11)

• 主引用文献: Perry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.; Fragment-based screening of programmed death ligand 1 (PD-L1).; Bioorg. Med. Chem. Lett., 29:786-790, 2019; PubMed: 30728114; DOI: 10.1016/j.bmcl.2019.01.028

実験手法

X-RAY DIFFRACTION (2.792 Å)