6NM0

Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines

6NM0 の概要

• エントリーDOI: 10.2210/pdb6nm0/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-[3-(2,4-difluorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]benzene-1-sulfonamide, ... (6 entities in total)
• 機能のキーワード: breast cancer, hypoxia, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29519.61

構造登録者

Singh, S.,McKenna, R. (登録日: 2019-01-10, 公開日: 2020-01-15, 最終更新日: 2023-10-11)

• 主引用文献: Mboge, M.Y.,Combs, J.,Singh, S.,Andring, J.,Wolff, A.,Tu, C.,Zhang, Z.,McKenna, R.,Frost, S.C.; Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.; J.Med.Chem., 64:1713-1724, 2021; PubMed: 33523653; DOI: 10.1021/acs.jmedchem.0c02077

実験手法

X-RAY DIFFRACTION (1.44 Å)