6NLH

Structure of human triose phosphate isomerase R189A

Summary for 6NLH

• Entry DOI: 10.2210/pdb6nlh/pdb
• Descriptor: Triosephosphate isomerase, SODIUM ION, BROMIDE ION, ... (5 entities in total)
• Functional Keywords: isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 210990.36

Authors

Richards, K.R.,Roland, B.P.,Palladino, M.J.,VanDemark, A.P. (deposition date: 2019-01-08, release date: 2019-06-19, Last modification date: 2023-10-11)

• Primary citation: Roland, B.P.,Richards, K.R.,Hrizo, S.L.,Eicher, S.,Barile, Z.J.,Chang, T.C.,Savon, G.,Bianchi, P.,Fermo, E.,Ricerca, B.M.,Tortorolo, L.,Vockley, J.,VanDemark, A.P.,Palladino, M.J.; Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.; Biochim Biophys Acta Mol Basis Dis, 1865:2257-2266, 2019; PubMed: 31075491; DOI: 10.1016/j.bbadis.2019.05.002

Experimental method

X-RAY DIFFRACTION (2.199 Å)