6NKM

Structure of PhqE D166N Reductase/Diels-Alderase from Penicillium fellutanum in complex with NADP+ and substrate

Summary for 6NKM

• Entry DOI: 10.2210/pdb6nkm/pdb
• Related: 6NKH 6NKK
• Descriptor: Short chain dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-8H-pyrrolo[1,2-a]pyrazin-5-ium-1-olate, ... (4 entities in total)
• Functional Keywords: reductase, diels-alderase, oxidoreductase
• Biological source: Penicillium fellutanum
• Total number of polymer chains: 6
• Total formula weight: 170113.60

Authors

Newmister, S.A.,Dan, Q.,Smith, J.L.,Sherman, D.H. (deposition date: 2019-01-07, release date: 2019-10-09, Last modification date: 2024-03-13)

• Primary citation: Dan, Q.,Newmister, S.A.,Klas, K.R.,Fraley, A.E.,McAfoos, T.J.,Somoza, A.D.,Sunderhaus, J.D.,Ye, Y.,Shende, V.V.,Yu, F.,Sanders, J.N.,Brown, W.C.,Zhao, L.,Paton, R.S.,Houk, K.N.,Smith, J.L.,Sherman, D.H.,Williams, R.M.; Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase.; Nat.Chem., 11:972-980, 2019; PubMed: 31548667; DOI: 10.1038/s41557-019-0326-6

Experimental method

X-RAY DIFFRACTION (1.896 Å)