6NJS

Stat3 Core in complex with compound SD36

6NJS の概要

• エントリーDOI: 10.2210/pdb6njs/pdb
• 分子名称: Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name) (3 entities in total)
• 機能のキーワード: stat3, activator, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65253.75

構造登録者

Meagher, J.L.,Stuckey, J.A. (登録日: 2019-01-04, 公開日: 2019-12-04, 最終更新日: 2023-10-11)

• 主引用文献: Bai, L.,Zhou, H.,Xu, R.,Zhao, Y.,Chinnaswamy, K.,McEachern, D.,Chen, J.,Yang, C.Y.,Liu, Z.,Wang, M.,Liu, L.,Jiang, H.,Wen, B.,Kumar, P.,Meagher, J.L.,Sun, D.,Stuckey, J.A.,Wang, S.; A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.; Cancer Cell, 36:498-511.e17, 2019; PubMed: 31715132; DOI: 10.1016/j.ccell.2019.10.002

実験手法

X-RAY DIFFRACTION (2.7 Å)