6NJ7
11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID
Summary for 6NJ7
Entry DOI | 10.2210/pdb6nj7/pdb |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid, ... (4 entities in total) |
Functional Keywords | dehydrogenase, inhibitor, complex, glucocorticoid regulation, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 132684.13 |
Authors | Miller, D.J.,Rivas, F. (deposition date: 2019-01-02, release date: 2019-07-24, Last modification date: 2023-10-11) |
Primary citation | Ling, T.,Miller, D.J.,Lang, W.H.,Griffith, E.,Rodriguez-Cortes, A.,El Ayachi, I.,Palacios, G.,Min, J.,Miranda-Carboni, G.,Lee, R.E.,Rivas, F. Mechanistic Insight on the Mode of Action of Colletoic Acid. J.Med.Chem., 62:6925-6940, 2019 Cited by PubMed: 31294974DOI: 10.1021/acs.jmedchem.9b00187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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