6NJ7

11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID

Summary for 6NJ7

Entry DOI	10.2210/pdb6nj7/pdb
Descriptor	Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid, ... (4 entities in total)
Functional Keywords	dehydrogenase, inhibitor, complex, glucocorticoid regulation, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	132684.13
Authors	Miller, D.J.,Rivas, F. (deposition date: 2019-01-02, release date: 2019-07-24, Last modification date: 2023-10-11)
Primary citation	Ling, T.,Miller, D.J.,Lang, W.H.,Griffith, E.,Rodriguez-Cortes, A.,El Ayachi, I.,Palacios, G.,Min, J.,Miranda-Carboni, G.,Lee, R.E.,Rivas, F. Mechanistic Insight on the Mode of Action of Colletoic Acid. J.Med.Chem., 62:6925-6940, 2019 Cited by PubMed: 31294974 DOI: 10.1021/acs.jmedchem.9b00187 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation