6NJ7

11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID

6NJ7 の概要

• エントリーDOI: 10.2210/pdb6nj7/pdb
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: dehydrogenase, inhibitor, complex, glucocorticoid regulation, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132684.13

構造登録者

Miller, D.J.,Rivas, F. (登録日: 2019-01-02, 公開日: 2019-07-24, 最終更新日: 2023-10-11)

• 主引用文献: Ling, T.,Miller, D.J.,Lang, W.H.,Griffith, E.,Rodriguez-Cortes, A.,El Ayachi, I.,Palacios, G.,Min, J.,Miranda-Carboni, G.,Lee, R.E.,Rivas, F.; Mechanistic Insight on the Mode of Action of Colletoic Acid.; J.Med.Chem., 62:6925-6940, 2019; PubMed: 31294974; DOI: 10.1021/acs.jmedchem.9b00187

実験手法

X-RAY DIFFRACTION (2.6 Å)