6NIZ

Atomic structure of a fluorescent Ag8 cluster templated by a multistranded DNA scaffold

6NIZ の概要

• エントリーDOI: 10.2210/pdb6niz/pdb
• 分子名称: DNA (5'-D(*AP*AP*CP*CP*CP*CP)-3'), SILVER ION (3 entities in total)
• 機能のキーワード: dna, silver, emissive cluster, nanocluster
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4770.78

構造登録者

Lieberman, R.L.,Huard, D.J.E. (登録日: 2019-01-02, 公開日: 2019-01-16, 最終更新日: 2024-03-13)

主引用文献

Huard, D.J.E.,Demissie, A.,Kim, D.,Lewis, D.,Dickson, R.M.,Petty, J.T.,Lieberman, R.L.
Atomic Structure of a Fluorescent Ag8Cluster Templated by a Multistranded DNA Scaffold.
J.Am.Chem.Soc., 141:11465-11470, 2019

PubMed Abstract: Multinuclear silver clusters encapsulated by DNA exhibit size-tunable emission spectra and rich photophysics, but their atomic organization is poorly understood. Herein, we describe the structure of one such hybrid chromophore, a green-emitting Ag cluster arranged in a Big Dipper-shape bound to the oligonucleotide AC. Three 3' cytosine metallo-base pairs stabilize a parallel A-form-like duplex with a 5' adenine-rich pocket, which binds a metallic, trapezoidal-shaped Ag moiety via Ag-N bonds to endo- and exocyclic nitrogens of cytosine and adenine. The unique DNA configuration, constrained coordination environment, and templated Ag cluster arrangement highlight the reciprocity between the silvers and DNA in adopting this structure. These first atomic details of a DNA-encapsulated Ag cluster fluorophore illuminate many aspects of biological assembly, nanoscience, and metal cluster photophysics.

PubMed: 30562465
DOI: 10.1021/jacs.8b12203

実験手法

X-RAY DIFFRACTION (0.93 Å)