6NI2
Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex
Summary for 6NI2
Entry DOI | 10.2210/pdb6ni2/pdb |
EMDB information | 9375 9376 9377 |
Descriptor | Nanobody 32, Beta-arrestin-1, Fab30 Heavy Chain, ... (5 entities in total) |
Functional Keywords | arrestin, gpcr signaling transducer, scaffolding protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Lama glama (Llama) More |
Total number of polymer chains | 5 |
Total formula weight | 110037.85 |
Authors | Nguyen, A.H.,Thomsen, A.R.B.,Cahill, T.J.,des Georges, A.,Lefkowitz, R.J. (deposition date: 2018-12-26, release date: 2019-11-20, Last modification date: 2019-12-18) |
Primary citation | Nguyen, A.H.,Thomsen, A.R.B.,Cahill 3rd, T.J.,Huang, R.,Huang, L.Y.,Marcink, T.,Clarke, O.B.,Heissel, S.,Masoudi, A.,Ben-Hail, D.,Samaan, F.,Dandey, V.P.,Tan, Y.Z.,Hong, C.,Mahoney, J.P.,Triest, S.,Little 4th, J.,Chen, X.,Sunahara, R.,Steyaert, J.,Molina, H.,Yu, Z.,des Georges, A.,Lefkowitz, R.J. Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26:1123-1131, 2019 Cited by PubMed: 31740855DOI: 10.1038/s41594-019-0330-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
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