6NFZ

Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.

6NFZ の概要

• エントリーDOI: 10.2210/pdb6nfz/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2 entities in total)
• 機能のキーワード: kinase, active state, dimer, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69986.55

構造登録者

Johnson, E.,McTigue, M.,Cronin, C.N. (登録日: 2018-12-21, 公開日: 2019-05-01, 最終更新日: 2019-06-26)

• 主引用文献: Johnson, E.,McTigue, M.,Gallego, R.A.,Johnson, T.W.,Timofeevski, S.,Maestre, M.,Fisher, T.S.,Kania, R.,Sawasdikosol, S.,Burakoff, S.,Cronin, C.N.; Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.; J.Biol.Chem., 294:9029-9036, 2019; PubMed: 31018963; DOI: 10.1074/jbc.AC119.007466

実験手法

X-RAY DIFFRACTION (2.966 Å)