6NEM

3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one bound to influenza 2009 pH1N1 endonuclease

6NEM の概要

• エントリーDOI: 10.2210/pdb6nem/pdb
• 関連するPDBエントリー: 6NEL
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one, ... (5 entities in total)
• 機能のキーワード: influenza endonuclease inhibitor chelator, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Influenza A virus (A/Luxembourg/43/2009(H1N1))
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29161.56

構造登録者

Bauman, J.D.,Arnold, E. (登録日: 2018-12-17, 公開日: 2019-05-01, 最終更新日: 2023-10-11)

• 主引用文献: Sagong, H.Y.,Bauman, J.D.,Nogales, A.,Martinez-Sobrido, L.,Arnold, E.,LaVoie, E.J.; Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.; Chemmedchem, 14:1204-1223, 2019; PubMed: 30983160; DOI: 10.1002/cmdc.201900084

実験手法

X-RAY DIFFRACTION (1.95 Å)