6NDL

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor

6NDL の概要

• エントリーDOI: 10.2210/pdb6ndl/pdb
• 分子名称: Biotin Protein Ligase, GLYCEROL, 1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea, ... (4 entities in total)
• 機能のキーワード: bpl inhibitor, sulfonamide analogue, amino sulfonylurea, antibiotic, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39058.99

構造登録者

Marshall, A.C.,Polyak, S.W.,Bruning, J.B.,Lee, K. (登録日: 2018-12-13, 公開日: 2019-12-18, 最終更新日: 2023-10-11)

• 主引用文献: Lee, K.J.,Tieu, W.,Blanco-Rodriguez, B.,Paparella, A.S.,Yu, J.,Hayes, A.,Feng, J.,Marshall, A.C.,Noll, B.,Milne, R.,Cini, D.,Wilce, M.C.J.,Booker, G.W.,Bruning, J.B.,Polyak, S.W.,Abell, A.D.; Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.; Acs Chem.Biol., 14:1990-1997, 2019; PubMed: 31407891; DOI: 10.1021/acschembio.9b00463

実験手法

X-RAY DIFFRACTION (2 Å)