6NCN
Fragment-based Discovery of an apoE4 Stabilizer
Summary for 6NCN
Entry DOI | 10.2210/pdb6ncn/pdb |
Descriptor | Apolipoprotein E, 1-(3-chlorophenyl)cyclobutane-1-carboximidamide (3 entities in total) |
Functional Keywords | lipid binding lipid transport, lipid transport |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 21731.91 |
Authors | Jakob, C.G.,Qiu, W. (deposition date: 2018-12-11, release date: 2019-04-17, Last modification date: 2023-10-11) |
Primary citation | Petros, A.M.,Korepanova, A.,Jakob, C.G.,Qiu, W.,Panchal, S.C.,Wang, J.,Dietrich, J.D.,Brewer, J.T.,Pohlki, F.,Kling, A.,Wilcox, K.,Lakics, V.,Bahnassawy, L.,Reinhardt, P.,Partha, S.K.,Bodelle, P.M.,Lake, M.,Charych, E.I.,Stoll, V.S.,Sun, C.,Mohler, E.G. Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer. J.Med.Chem., 62:4120-4130, 2019 Cited by PubMed: 30933499DOI: 10.1021/acs.jmedchem.9b00178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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