6NBS

WT ERK2 with compound 2507-8

Summary for 6NBS

Entry DOI	10.2210/pdb6nbs/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	inhibitor, mapk, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	43270.85
Authors	Sammons, R.M.,Perry, N.A.,Cho, E.J.,Kaoud, T.S.,Zamora-Olivares, D.P.,Piserchio, A.,Houghten, R.A.,Giulianotti, M.,Li, Y.,Debevec, G.,Gurevich, V.V.,Ghose, R.,Iverson, T.M.,Dalby, K.N. (deposition date: 2018-12-10, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Sammons, R.M.,Perry, N.A.,Li, Y.,Cho, E.J.,Piserchio, A.,Zamora-Olivares, D.P.,Ghose, R.,Kaoud, T.S.,Debevec, G.,Bartholomeusz, C.,Gurevich, V.V.,Iverson, T.M.,Giulianotti, M.,Houghten, R.A.,Dalby, K.N. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. Acs Chem.Biol., 14:1183-1194, 2019 Cited by PubMed: 31058487 DOI: 10.1021/acschembio.9b00093 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation