6NBS

WT ERK2 with compound 2507-8

6NBS の概要

• エントリーDOI: 10.2210/pdb6nbs/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: inhibitor, mapk, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43270.85

構造登録者

Sammons, R.M.,Perry, N.A.,Cho, E.J.,Kaoud, T.S.,Zamora-Olivares, D.P.,Piserchio, A.,Houghten, R.A.,Giulianotti, M.,Li, Y.,Debevec, G.,Gurevich, V.V.,Ghose, R.,Iverson, T.M.,Dalby, K.N. (登録日: 2018-12-10, 公開日: 2019-07-31, 最終更新日: 2023-10-11)

• 主引用文献: Sammons, R.M.,Perry, N.A.,Li, Y.,Cho, E.J.,Piserchio, A.,Zamora-Olivares, D.P.,Ghose, R.,Kaoud, T.S.,Debevec, G.,Bartholomeusz, C.,Gurevich, V.V.,Iverson, T.M.,Giulianotti, M.,Houghten, R.A.,Dalby, K.N.; A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.; Acs Chem.Biol., 14:1183-1194, 2019; PubMed: 31058487; DOI: 10.1021/acschembio.9b00093

実験手法

X-RAY DIFFRACTION (1.9 Å)