6NBI

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

6NBI の概要

• エントリーDOI: 10.2210/pdb6nbi/pdb
• EMDBエントリー: 0412 4010 4011
• 分子名称: Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ... (7 entities in total)
• 機能のキーワード: parathyroid hormone receptor, gpcr, class b gpcr, gpcr-g protein complex, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 163544.68

構造登録者

Zhao, L.-H.,Ma, S.,Sutkeviciute, I.,Shen, D.-D.,Zhou, X.E.,de Waal, P.P.,Li, C.-Y.,Kang, Y.,Clark, L.J.,Jean-Alphonse, F.G.,White, A.D.,Xiao, K.,Yang, D.,Jiang, Y.,Watanabe, T.,Gardella, T.J.,Melcher, K.,Wang, M.-W.,Vilardaga, J.-P.,Xu, H.E.,Zhang, Y. (登録日: 2018-12-07, 公開日: 2019-04-17, 最終更新日: 2019-12-18)

• 主引用文献: Zhao, L.H.,Ma, S.,Sutkeviciute, I.,Shen, D.D.,Zhou, X.E.,de Waal, P.W.,Li, C.Y.,Kang, Y.,Clark, L.J.,Jean-Alphonse, F.G.,White, A.D.,Yang, D.,Dai, A.,Cai, X.,Chen, J.,Li, C.,Jiang, Y.,Watanabe, T.,Gardella, T.J.,Melcher, K.,Wang, M.W.,Vilardaga, J.P.,Xu, H.E.,Zhang, Y.; Structure and dynamics of the active human parathyroid hormone receptor-1.; Science, 364:148-153, 2019; PubMed: 30975883; DOI: 10.1126/science.aav7942

実験手法

ELECTRON MICROSCOPY (4 Å)