6N9T

Structure of a peptide-based photo-affinity cross-linker with Herceptin Fc

6N9T の概要

• エントリーDOI: 10.2210/pdb6n9t/pdb
• 分子名称: Immunoglobulin G1 FC, Photo-affinity peptide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: crosslinking, antibody, photo-reactive, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56371.25

構造登録者

Sadowsky, J.,Ultsch, M.,Vance, N.,Wang, W. (登録日: 2018-12-04, 公開日: 2019-01-16, 最終更新日: 2020-07-29)

• 主引用文献: Vance, N.,Zacharias, N.,Ultsch, M.,Li, G.,Fourie, A.,Liu, P.,LaFrance-Vanasse, J.,Ernst, J.A.,Sandoval, W.,Kozak, K.R.,Phillips, G.,Wang, W.,Sadowsky, J.; Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.; Bioconjug. Chem., 30:148-160, 2019; PubMed: 30566343; DOI: 10.1021/acs.bioconjchem.8b00809

実験手法

X-RAY DIFFRACTION (2.576 Å)