6N8X

Hsp90-alpha bound to PU-11-trans

6N8X の概要

• エントリーDOI: 10.2210/pdb6n8x/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine (3 entities in total)
• 機能のキーワード: hsp90, inhibitor, cancer, cytosol, chaperone, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29142.56

構造登録者

Huck, J.D.,Que, N.L.S.,Gewirth, D.T. (登録日: 2018-11-30, 公開日: 2019-07-03, 最終更新日: 2024-03-13)

• 主引用文献: Huck, J.D.,Que, N.L.S.,Sharma, S.,Taldone, T.,Chiosis, G.,Gewirth, D.T.; Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.; Proteins, 87:869-877, 2019; PubMed: 31141217; DOI: 10.1002/prot.25750

実験手法

X-RAY DIFFRACTION (1.49484474369 Å)