6N8D

Crystal structure of GII.4 2002 norovirus P domain in complex with neutralizing human antibody A1431

Summary for 6N8D

• Entry DOI: 10.2210/pdb6n8d/pdb
• Related: 6N81
• Descriptor: Major capsid protein, A1431 Fab light chain, A1431 Fab heavy chain (3 entities in total)
• Functional Keywords: norovirus, human antibody, fab, complex, neutralizing, immune system
• Biological source: Norovirus Hu/GII.4/Farmington Hills/2004/USA; More
• Total number of polymer chains: 6
• Total formula weight: 164775.61

Authors

Changela, A.,Verardi, R.,Kwong, P.D. (deposition date: 2018-11-29, release date: 2019-06-19, Last modification date: 2023-10-11)

• Primary citation: Lindesmith, L.C.,McDaniel, J.R.,Changela, A.,Verardi, R.,Kerr, S.A.,Costantini, V.,Brewer-Jensen, P.D.,Mallory, M.L.,Voss, W.N.,Boutz, D.R.,Blazeck, J.J.,Ippolito, G.C.,Vinje, J.,Kwong, P.D.,Georgiou, G.,Baric, R.S.; Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.; Immunity, 50:1530-1541.e8, 2019; PubMed: 31216462; DOI: 10.1016/j.immuni.2019.05.007

Experimental method

X-RAY DIFFRACTION (3.1 Å)