6N82

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037

6N82 の概要

• エントリーDOI: 10.2210/pdb6n82/pdb
• 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid, ... (8 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44570.94

構造登録者

Park, J.,Schilling, M.A.,Berghuis, A.M. (登録日: 2018-11-28, 公開日: 2019-11-06, 最終更新日: 2023-10-11)

• 主引用文献: Feng, Y.,Park, J.,Li, S.G.,Boutin, R.,Viereck, P.,Schilling, M.A.,Berghuis, A.M.,Tsantrizos, Y.S.; Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).; J.Med.Chem., 62:9691-9702, 2019; PubMed: 31577901; DOI: 10.1021/acs.jmedchem.9b01104

実験手法

X-RAY DIFFRACTION (2 Å)