6N81

Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227

Summary for 6N81

Entry DOI	10.2210/pdb6n81/pdb
Descriptor	Major capsid protein, A1227 Fab light chain, A1227 Fab heavy chain, ... (4 entities in total)
Functional Keywords	norovirus, human antibody, complex, fab, immune system
Biological source	Norovirus Hu/GII.4/Farmington Hills/2004/USA More
Total number of polymer chains	6
Total formula weight	163922.68
Authors	Changela, A.,Verardi, R.,Kwong, P.D. (deposition date: 2018-11-28, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	Lindesmith, L.C.,McDaniel, J.R.,Changela, A.,Verardi, R.,Kerr, S.A.,Costantini, V.,Brewer-Jensen, P.D.,Mallory, M.L.,Voss, W.N.,Boutz, D.R.,Blazeck, J.J.,Ippolito, G.C.,Vinje, J.,Kwong, P.D.,Georgiou, G.,Baric, R.S. Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination. Immunity, 50:1530-1541.e8, 2019 Cited by PubMed: 31216462 DOI: 10.1016/j.immuni.2019.05.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.579 Å)

Structure validation