6N7G

Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I)

Summary for 6N7G

• Entry DOI: 10.2210/pdb6n7g/pdb
• EMDB information: 0355
• Descriptor: Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: receptor, rnd family, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 650738.67

Authors

Yan, N.,Gong, X.,Qian, H.W. (deposition date: 2018-11-27, release date: 2019-05-29, Last modification date: 2020-07-29)

• Primary citation: Qian, H.,Cao, P.,Hu, M.,Gao, S.,Yan, N.,Gong, X.; Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.; Nat Commun, 10:2320-2320, 2019; PubMed: 31127104; DOI: 10.1038/s41467-019-10234-9

Experimental method

ELECTRON MICROSCOPY (6.8 Å)