6N4Q
CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2
Summary for 6N4Q
Entry DOI | 10.2210/pdb6n4q/pdb |
EMDB information | 0341 |
Descriptor | Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ... (4 entities in total) |
Functional Keywords | voltage-gated sodium channel, gating modifier toxin, membrane protein |
Biological source | Arcobacter butzleri (strain RM4018) More |
Total number of polymer chains | 12 |
Total formula weight | 245187.65 |
Authors | Xu, H.,Rohou, A.,Arthur, C.P.,Estevez, A.,Ciferri, C.,Payandeh, J.,Koth, C.M. (deposition date: 2018-11-20, release date: 2019-01-23, Last modification date: 2019-12-18) |
Primary citation | Xu, H.,Li, T.,Rohou, A.,Arthur, C.P.,Tzakoniati, F.,Wong, E.,Estevez, A.,Kugel, C.,Franke, Y.,Chen, J.,Ciferri, C.,Hackos, D.H.,Koth, C.M.,Payandeh, J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176:702-, 2019 Cited by PubMed: 30661758DOI: 10.1016/j.cell.2018.12.018 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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