6N4O

Human Argonaute2-miR-122 bound to a seed and supplementary paired target

Summary for 6N4O

• Entry DOI: 10.2210/pdb6n4o/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3'), RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') (3 entities in total)
• Functional Keywords: rna-binding protein, microrna, target directed microrna decay, hydrolase-rna complex, rna binding protein, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 109782.63

Authors

Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2018-11-19, release date: 2019-05-08, Last modification date: 2023-10-11)

• Primary citation: Sheu-Gruttadauria, J.,Xiao, Y.,Gebert, L.F.,MacRae, I.J.; Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2.; Embo J., 38:e101153-e101153, 2019; PubMed: 31268608; DOI: 10.15252/embj.2018101153

Experimental method

X-RAY DIFFRACTION (2.899 Å)