6N48

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

Summary for 6N48

DescriptorEndolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ... (5 entities in total)
Functional Keywordsg protein coupled receptor, membrane protein, signaling protein
Biological sourceEnterobacteria phage RB59
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Total number of polymer chains2
Total molecular weight67761.14
Authors
Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Hirata, K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.K. (deposition date: 2018-11-17, release date: 2019-06-26, Last modification date: 2019-07-10)
Primary citation
Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Staus, D.P.,Shim, P.J.,Hirata, K.,Simhal, R.K.,Schwalb, A.M.,Rambarat, P.K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.
Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.
Science, 364:1283-1287, 2019
PubMed: 31249059 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaw8981
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28170 0.2% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution