Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

Summary for 6N48

DescriptorEndolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ... (5 entities in total)
Functional Keywordsg protein coupled receptor, membrane protein, signaling protein
Biological sourceEnterobacteria phage RB59
Total number of polymer chains2
Total molecular weight67761.14
Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Hirata, K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.K. (deposition date: 2018-11-17, release date: 2019-06-26, Last modification date: 2019-07-10)
Primary citation
Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Staus, D.P.,Shim, P.J.,Hirata, K.,Simhal, R.K.,Schwalb, A.M.,Rambarat, P.K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.
Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.
Science, 364:1283-1287, 2019
PubMed: 31249059 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaw8981
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28170 0.2% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution