6N1T

Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3

Summary for 6N1T

Entry DOI	10.2210/pdb6n1t/pdb
Related	4eil 6aog 6aoh 6aoi 6n1s
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	toxoplasma gondii, dhfr, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Toxoplasma gondii
Total number of polymer chains	2
Total formula weight	132247.63
Authors	Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S.B. (deposition date: 2018-11-11, release date: 2019-01-23, Last modification date: 2023-10-11)
Primary citation	Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J. Med. Chem., 62:1562-1576, 2019 Cited by PubMed: 30624926 DOI: 10.1021/acs.jmedchem.8b01754 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation