6N1T

Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3

6N1T の概要

• エントリーDOI: 10.2210/pdb6n1t/pdb
• 関連するPDBエントリー: 4eil 6aog 6aoh 6aoi 6n1s
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: toxoplasma gondii, dhfr, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 132247.63

構造登録者

Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S.B. (登録日: 2018-11-11, 公開日: 2019-01-23, 最終更新日: 2023-10-11)

• 主引用文献: Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S.; Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.; J. Med. Chem., 62:1562-1576, 2019; PubMed: 30624926; DOI: 10.1021/acs.jmedchem.8b01754

実験手法

X-RAY DIFFRACTION (3.5 Å)