6N1S
Toxoplasma gondii TS-DHFR in complex with selective inhibitor 29
Summary for 6N1S
| Entry DOI | 10.2210/pdb6n1s/pdb |
| Related | 4eil 6aog 6aoh 6aoi 6n1t |
| Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
| Functional Keywords | toxoplasma gondii, dhfr, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Toxoplasma gondii |
| Total number of polymer chains | 2 |
| Total formula weight | 132277.70 |
| Authors | Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S.B. (deposition date: 2018-11-11, release date: 2019-01-23, Last modification date: 2023-10-11) |
| Primary citation | Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J. Med. Chem., 62:1562-1576, 2019 Cited by PubMed: 30624926DOI: 10.1021/acs.jmedchem.8b01754 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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