6N0O

Crystal structure of Tdp1 catalytic domain in complex with compound XZ523

Summary for 6N0O

• Entry DOI: 10.2210/pdb6n0o/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, 4-nitrobenzene-1,2-dicarboxylic acid, ... (4 entities in total)
• Functional Keywords: fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 104923.20

Authors

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-07, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S.; Crystal structure of Tdp1 catalytic domain; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.943 Å)