6MYZ
Crystal structure of Tdp1 catalytic domain in complex with compound XZ520
Summary for 6MYZ
Entry DOI | 10.2210/pdb6myz/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 104828.28 |
Authors | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-02, release date: 2019-11-06, Last modification date: 2023-10-11) |
Primary citation | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. Structure of Tdp1 catalytic domain in complex with compound XZ520 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.661 Å) |
Structure validation
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