6MYZ

Crystal structure of Tdp1 catalytic domain in complex with compound XZ520

6MYZ の概要

• エントリーDOI: 10.2210/pdb6myz/pdb
• 分子名称: Tyrosyl-DNA phosphodiesterase 1, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104828.28

構造登録者

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (登録日: 2018-11-02, 公開日: 2019-11-06, 最終更新日: 2023-10-11)

• 主引用文献: Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S.; Structure of Tdp1 catalytic domain in complex with compound XZ520; To Be Published,

実験手法

X-RAY DIFFRACTION (1.661 Å)