6MYN

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7

Summary for 6MYN

• Entry DOI: 10.2210/pdb6myn/pdb
• Related: 4G3C
• Descriptor: Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, (5s,7s)-9-fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-yn-1-yl]-N~3~-methyl-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide, ... (4 entities in total)
• Functional Keywords: nik, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 78205.88

Authors

Harris, S.F.,Smith, M.,Barker, J. (deposition date: 2018-11-01, release date: 2019-08-07, Last modification date: 2024-03-13)

• Primary citation: Feng, J.A.,Lee, P.,Alaoui, M.H.,Barrett, K.,Castanedo, G.,Godemann, R.,McEwan, P.,Wang, X.,Wu, P.,Zhang, Y.,Harris, S.F.,Staben, S.T.; Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).; Acs Med.Chem.Lett., 10:1260-1265, 2019; PubMed: 31531194; DOI: 10.1021/acsmedchemlett.8b00658

Experimental method

X-RAY DIFFRACTION (2.744 Å)