6MYE
Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)
Summary for 6MYE
Entry DOI | 10.2210/pdb6mye/pdb |
Descriptor | Protein scribble homolog, Rho guanine nucleotide exchange factor 26, peptide, FORMIC ACID, ... (4 entities in total) |
Functional Keywords | guanyl nucleotide exchange factor, sgef/scribble/dlg1 compelx, cell adhesion, tight junction |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 11182.62 |
Authors | Sun, Y.J.,Hou, T.,Gakhar, L.,Fuentes, E.J. (deposition date: 2018-11-01, release date: 2019-04-10, Last modification date: 2023-10-11) |
Primary citation | Awadia, S.,Huq, F.,Arnold, T.R.,Goicoechea, S.M.,Sun, Y.J.,Hou, T.,Kreider-Letterman, G.,Massimi, P.,Banks, L.,Fuentes, E.J.,Miller, A.L.,Garcia-Mata, R. SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility. J.Cell Biol., 218:2699-2725, 2019 Cited by PubMed: 31248911DOI: 10.1083/jcb.201811114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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