6MY0
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
Summary for 6MY0
Entry DOI | 10.2210/pdb6my0/pdb |
Descriptor | TP53-binding protein 1 (2 entities in total) |
Functional Keywords | 53bp1, dna damage response, dna double-strand breaks, tudor domain, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 27823.59 |
Authors | Cui, G.,Botuyan, M.V.,Mer, G. (deposition date: 2018-10-31, release date: 2019-11-27, Last modification date: 2023-10-11) |
Primary citation | Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14:6091-6091, 2023 Cited by PubMed: 37773238DOI: 10.1038/s41467-023-41821-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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