6MXT

Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71

Replaces:  6CSY

Summary for 6MXT

• Entry DOI: 10.2210/pdb6mxt/pdb
• Descriptor: Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, salmeterol, ... (10 entities in total)
• Functional Keywords: g protein-coupled receptor, adrenergic receptor, asthma drug, active conformation, nanobody, signaling protein-hormone complex, membrane protein, signaling protein/hormone
• Biological source: Enterobacteria phage T4; More
• Total number of polymer chains: 2
• Total formula weight: 68731.36

Authors

Masureel, M.,Zou, Y.,Picard, L.P.,van der Westhuizen, E.,Mahoney, J.P.,Rodrigues, J.P.G.L.M.,Mildorf, T.J.,Dror, R.O.,Shaw, D.E.,Bouvier, M.,Pardon, E.,Steyaert, J.,Sunahara, R.K.,Weis, W.I.,Zhang, C.,Kobilka, B.K. (deposition date: 2018-10-31, release date: 2018-11-14, Last modification date: 2023-10-11)

• Primary citation: Masureel, M.,Zou, Y.,Picard, L.P.,van der Westhuizen, E.,Mahoney, J.P.,Rodrigues, J.P.G.L.M.,Mildorf, T.J.,Dror, R.O.,Shaw, D.E.,Bouvier, M.,Pardon, E.,Steyaert, J.,Sunahara, R.K.,Weis, W.I.,Zhang, C.,Kobilka, B.K.; Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.; Nat. Chem. Biol., 14:1059-1066, 2018; PubMed: 30327561; DOI: 10.1038/s41589-018-0145-x

Experimental method

X-RAY DIFFRACTION (2.95934213525 Å)