6MV8

LDHA structure in complex with inhibitor 14

Summary for 6MV8

• Entry DOI: 10.2210/pdb6mv8/pdb
• Related: 6BAD 6BAG 6BB3
• Descriptor: L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: ldha, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 152064.39

Authors

Eigenbrot, C.E.,Ultsch, M.,Wei, B. (deposition date: 2018-10-24, release date: 2019-10-30, Last modification date: 2023-11-15)

• Primary citation: Wei, B.,Robarge, K.,Labadie, S.S.,Chen, J.,Corson, L.B.,DiPasquale, A.,Eigenbrot, C.,Ultsch, M.; Structure-based Optimization of Potent, Cell-Active Hydroxylactam Inhibitors of Lactate Dehydrogenase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)