6MV8
LDHA structure in complex with inhibitor 14
Summary for 6MV8
Entry DOI | 10.2210/pdb6mv8/pdb |
Related | 6BAD 6BAG 6BB3 |
Descriptor | L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | ldha, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 152064.39 |
Authors | Eigenbrot, C.E.,Ultsch, M.,Wei, B. (deposition date: 2018-10-24, release date: 2019-10-30, Last modification date: 2023-11-15) |
Primary citation | Wei, B.,Robarge, K.,Labadie, S.S.,Chen, J.,Corson, L.B.,DiPasquale, A.,Eigenbrot, C.,Ultsch, M. Structure-based Optimization of Potent, Cell-Active Hydroxylactam Inhibitors of Lactate Dehydrogenase To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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