6MU7

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom

Summary for 6MU7

DescriptorEnvelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ... (11 entities in total)
Functional Keywordshiv-1 envelope prefusion trimer, entry inhibitors, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHuman immunodeficiency virus 1
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Total number of polymer chains6
Total molecular weight156707.52
Authors
Lai, Y.-T.,Kwong, P.D. (deposition date: 2018-10-22, release date: 2019-01-16)
Primary citation
Lai, Y.T.,Wang, T.,O'Dell, S.,Louder, M.K.,Schon, A.,Cheung, C.S.F.,Chuang, G.Y.,Druz, A.,Lin, B.,McKee, K.,Peng, D.,Yang, Y.,Zhang, B.,Herschhorn, A.,Sodroski, J.,Bailer, R.T.,Doria-Rose, N.A.,Mascola, J.R.,Langley, D.R.,Kwong, P.D.
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10:47-47, 2019
PubMed: 30604750 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-07851-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.501 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2617 0.2% 1.9% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6mu7
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Molmil generated image of 6mu7
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Molmil generated image of 6mu7
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More Biological unit images

Molmil generated image of 6mu7
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Molmil generated image of 6mu7
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Molmil generated image of 6mu7
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6mu7.pdb1.gz [622.21 KB])
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