Cryo-EM structure of human AA amyloid fibril

Summary for 6MST

EMDB information9232
DescriptorSerum amyloid A-1 protein (1 entity in total)
Functional Keywordsaa-amyloidosis, serum amyloid a, cross-beta, helical, protein fibril
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight89773.85
Loerch, S.,Rennegarbe, M.,Liberta, F.,Grigorieff, N.,Fandrich, M.,Schmidt, M. (deposition date: 2018-10-18, release date: 2019-03-13)
Primary citation
Liberta, F.,Loerch, S.,Rennegarbe, M.,Schierhorn, A.,Westermark, P.,Westermark, G.T.,Hazenberg, B.P.C.,Grigorieff, N.,Fandrich, M.,Schmidt, M.
Cryo-EM fibril structures from systemic amyloidosis provide insights into the species barrier of prion-like cross-seeding
To Be Published,
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers100MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6mst
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Molmil generated image of 6mst
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Molmil generated image of 6mst
rotated about y axis by 90°