6MSS

Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies

6MSS の概要

• エントリーDOI: 10.2210/pdb6mss/pdb
• 分子名称: A11B8.2 NKT TCR alpha-chain, A11B8.2 NKT TCR beta-chain, Antigen-presenting glycoprotein CD1d1, ... (8 entities in total)
• 機能のキーワード: nkt cells, cd1d molecule, microbial lipid antigen, immune system
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98046.75

構造登録者

Sundararaj, S.,Le Nours, J.,Praveena, T.,Rossjohn, J. (登録日: 2018-10-18, 公開日: 2019-10-02, 最終更新日: 2024-11-06)

主引用文献

Almeida, C.F.,Sundararaj, S.,Le Nours, J.,Praveena, T.,Cao, B.,Burugupalli, S.,Smith, D.G.M.,Patel, O.,Brigl, M.,Pellicci, D.G.,Williams, S.J.,Uldrich, A.P.,Godfrey, D.I.,Rossjohn, J.
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.
Nat Commun, 10:5242-5242, 2019

PubMed Abstract: Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our knowledge of type II NKT cells in health and disease remains unclear. Here we describe a population of type II NKT cells that recognise and respond to the microbial antigen, α-glucuronosyl-diacylglycerol (α-GlcADAG) presented by CD1d, but not the prototypical type I NKT cell agonist, α-galactosylceramide. Surprisingly, the crystal structure of a type II NKT TCR-CD1d-α-GlcADAG complex reveals a CD1d F'-pocket-docking mode that contrasts sharply with the previously determined A'-roof positioning of a sulfatide-reactive type II NKT TCR. Our data also suggest that diverse type II NKT TCRs directed against distinct microbial or mammalian lipid antigens adopt multiple recognition strategies on CD1d, thereby maximising the potential for type II NKT cells to detect different lipid antigens.

PubMed: 31748533
DOI: 10.1038/s41467-019-12941-9

実験手法

X-RAY DIFFRACTION (3 Å)