6MSB

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a large structure.

Summary for 6MSB

EMDB information9216 9215 9217 9218 9219 9220 9221 9222 9223 9224 9225 9226 9227 9228 9229
Descriptor26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 3, 26S proteasome non-ATPase regulatory subunit 12, ... (37 entities in total)
Functional Keywordsproteosome, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains48
Total molecular weight1681814.9
Authors
Mao, Y.D. (deposition date: 2018-10-16, release date: 2018-12-05, Last modification date: 2019-01-16)
Primary citation
Dong, Y.,Zhang, S.,Wu, Z.,Li, X.,Wang, W.L.,Zhu, Y.,Stoilova-McPhie, S.,Lu, Y.,Finley, D.,Mao, Y.
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565:49-55, 2019
PubMed: 30479383 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0736-4
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers5 0.3% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6msb
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Molmil generated image of 6msb
rotated about x axis by 90°
Molmil generated image of 6msb
rotated about y axis by 90°
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