6MQG
Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1
Summary for 6MQG
Entry DOI | 10.2210/pdb6mqg/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE (3 entities in total) |
Functional Keywords | gtpase kras hydrolysis, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19512.69 |
Authors | Bera, A.K.,Westover, K.D. (deposition date: 2018-10-09, release date: 2019-07-31, Last modification date: 2023-11-15) |
Primary citation | Bera, A.K.,Lu, J.,Wales, T.E.,Gondi, S.,Gurbani, D.,Nelson, A.,Engen, J.R.,Westover, K.D. Structural basis of the atypical activation mechanism of KRASV14I. J.Biol.Chem., 294:13964-13972, 2019 Cited by PubMed: 31341022DOI: 10.1074/jbc.RA119.009131 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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