6MPQ

1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514

6MPQ の概要

• エントリーDOI: 10.2210/pdb6mpq/pdb
• 分子名称: Beta-lactamase, (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: beta-lactamase, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28048.56

構造登録者

van den Akker, F.,Kumar, V. (登録日: 2018-10-08, 公開日: 2019-02-27, 最終更新日: 2023-11-15)

• 主引用文献: Barnes, M.D.,Kumar, V.,Bethel, C.R.,Moussa, S.H.,O'Donnell, J.,Rutter, J.D.,Good, C.E.,Hujer, K.M.,Hujer, A.M.,Marshall, S.H.,Kreiswirth, B.N.,Richter, S.S.,Rather, P.N.,Jacobs, M.R.,Papp-Wallace, K.M.,van den Akker, F.,Bonomo, R.A.; Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.; MBio, 10:-, 2019; PubMed: 30862744; DOI: 10.1128/mBio.00159-19

実験手法

X-RAY DIFFRACTION (1.95 Å)