6MOZ

Structure of acid-beta-glucosidase in complex with an aromatic pyrrolidine iminosugar inhibitor

6MOZ の概要

• エントリーDOI: 10.2210/pdb6moz/pdb
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (7 entities in total)
• 機能のキーワード: tim-barrel, glycosidase, cerezyme, hydrolysis, hydrolase, inhibitor complex, pharmacological chaperone
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113449.53

構造登録者

Patterson-Orazem, A.C.,Lieberman, R.L. (登録日: 2018-10-05, 公開日: 2019-06-19, 最終更新日: 2023-10-11)

• 主引用文献: Martinez-Bailen, M.,Carmona, A.T.,Patterson-Orazem, A.C.,Lieberman, R.L.,Ide, D.,Kubo, M.,Kato, A.,Robina, I.,Moreno-Vargas, A.J.; Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of beta-glucocerebrosidase inhibition.; Bioorg.Chem., 86:652-664, 2019; PubMed: 30825709; DOI: 10.1016/j.bioorg.2019.02.025

実験手法

X-RAY DIFFRACTION (2.1 Å)